Ingredient · Mineral · Companion Stack

Magnesium Glycinate

Magnesium bisglycinate

(magnesium chelated to two glycine molecules). Mineral / amino-acid chelate.

Companion-stack mineral — relaxation, sleep quality, and nervous-system tone support.

Suggested Dose

200–400mg Elemental

Used With

Evening · Off-Days

Evidence

Tier 1 Nutrition · Tier 2 Sleep

A well-tolerated, well-absorbed form of magnesium that supports relaxation and sleep quality — MYKO suggests it as an evening companion to the rest of the line.

What It Is

A well-tolerated, well-absorbed magnesium form.

Magnesium glycinate is magnesium chelated to glycine — one of the better-tolerated and most-absorbed forms of magnesium supplementation. Its glycine binding contributes to its relaxation profile (glycine itself is an inhibitory neurotransmitter), and it is generally easier on the GI tract than magnesium oxide or citrate.

Magnesium glycinate is not present in any current MYKO capsule formulation. This monograph supports the MYKO website's Education / Stack pages and any future companion-stack product. All copy is framed as protocol education.

Why MYKO Uses It

The wind-down counterweight to morning energy.

MYKO references magnesium glycinate as a companion-stack option for evening, off-day, and recovery days within MYKO protocol design — supportive of the parasympathetic, restorative profile that complements the line.

Found In MYKO Formulas

Where Magnesium Glycinate appears in the line.

Effects & Experience

A quieter evening, easier sleep onset.

Customers most often describe a quieter evening, easier muscle relaxation, and smoother sleep onset. Effects are usually noticed within 1–2 weeks.

Within MYKO protocol design, magnesium glycinate is positioned as the evening / off-day companion — the wind-down counterpart to Cordyceps's morning energy.

Key Bioactive Compounds

The chemistry MYKO selects for.

Elemental magnesium

An essential mineral cofactor in 300+ enzymatic reactions including ATP synthesis, neurotransmitter regulation, and muscle / nerve function.
Glycine

Amino acid and inhibitory neurotransmitter associated with relaxation and sleep onset.
Chelate form

Generally well-tolerated compared with magnesium oxide; lower laxative effect than citrate.

Mechanisms in the Body

Three pathways, three evidence levels.

Mechanism strength is presented separately so you can see what is human-supported, what is preclinical, and what is traditional theory.

Human-Supported

Magnesium supplementation has been shown to improve sleep onset and quality in older adults with insomnia symptoms in small RCTs.
Magnesium status is associated with mood, anxiety, and stress-resilience markers in observational human studies.

Preclinical / Mechanistic

Magnesium acts as a natural calcium antagonist at the NMDA receptor, contributing to excitation-inhibition balance.
Cofactor in ATP synthesis, GABA receptor modulation, and parathyroid hormone regulation.

Traditional / Theoretical

Magnesium has long been associated with relaxation in nutritional and bath / Epsom salt traditions; magnesium-rich diets are characteristic of many traditional eating patterns.

Evidence Grade

How MYKO grades this ingredient.

Overall Grade

Tier 1 for magnesium status as an essential mineral; Tier 2 for sleep / relaxation outcomes in supplementation; Tier 2–3 for mood and stress-resilience markers.

Strongest Areas

Magnesium's essential mineral status (Tier 1 nutritional); sleep-quality outcomes in deficient or insufficient populations (Tier 2).

Weaker / Emerging

Specific anxiolytic claims in already-replete populations; specific cognitive claims.

Claim Caution

Low

Reason

Magnesium is one of the safer companion supplements at typical doses. Cautions are kidney-related and dose-related rather than mechanism-related.

Science Hub

For the customer who wants the full picture.

Read the Deeper Technical Version

Magnesium glycinate (magnesium bisglycinate) is one of the better-absorbed and -tolerated forms of magnesium supplementation. Its mechanism is twofold: elemental magnesium contributes to NMDA receptor antagonism, GABA receptor modulation, ATP synthesis, and muscle / nerve function; the glycine moiety contributes inhibitory-neurotransmitter activity associated with relaxation and sleep onset.

Human evidence for magnesium supplementation is led by sleep-quality outcomes in older adults and in populations with subclinical insufficiency. Anxiolytic and mood evidence is observational and modest in already-replete populations.

Within MYKO protocol design, magnesium glycinate is positioned as the evening / off-day companion — supportive of the parasympathetic profile that complements the line. It is not in any current MYKO capsule formulation.

References

Direct human-outcome citations specific to this ingredient are limited or not yet referenced inline on this page. See the MYKO Ingredient Hub for the full evidence base, and the Science page for the broader formulation literature.

Safety Notes

What to know before using.

Use caution with kidney disease — kidneys regulate magnesium clearance.
May interact with antibiotics (particularly tetracyclines and quinolones), bisphosphonates, and some blood-pressure medications. Space dosing.
GI tolerance varies; loose stool is the most common side effect at high doses.
Most adults tolerate 200–400mg elemental magnesium per day comfortably.
Use caution in pregnancy and breastfeeding — defer to practitioner guidance on dosing.

Research Notes

What's supported, what's emerging.

What is reasonably supported: magnesium's essential mineral role; sleep-quality outcomes in deficient or insufficient populations.

What is still emerging: anxiolytic effects in already-replete populations; magnesium's role in long-term cognitive aging.

What should not be claimed strongly: "cures insomnia," "treats anxiety," "prevents migraine," or any disease-state claim.

Where more human research is needed: form-specific comparisons (glycinate vs. citrate vs. malate vs. threonate) for specific outcomes.

Where It Leads

Meet the formulas built on it.

Every MYKO ingredient earns its place in a formula. See the systems it powers — or find the one built for you.

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Explore Ingredients

All Twelve in MYKO's Library.

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These statements have not been evaluated by the U.S. Food and Drug Administration. MYKO products are not intended to diagnose, treat, cure, or prevent any disease.

Information on this site is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment. Consult a qualified healthcare practitioner before beginning any new supplement, particularly if you are pregnant, breastfeeding, taking medication, or managing a medical condition.